Building up complexity in structural biology studies

TL;DR

This paper discusses how cryo-electron microscopy is helping scientists study complex molecular structures in cells.

Contribution

The paper highlights cryo-electron microscopy's role in studying increasingly complex and dynamic molecular assemblies.

Findings

Structural biology is moving toward studying larger and more dynamic molecular assemblies.

Cryo-electron microscopy is becoming a key tool for these complex studies.

Abstract

Macromolecules are involved in myriads of interactions that regulate their cellular function. While years of structural biology progress was built by reducing this complexity, a molecular understanding of biological processes requires the characterization of ever larger and more dynamic molecular assemblies. Cryo-electron microscopy is rising to this challenge.