# Building up complexity in structural biology studies

**Authors:** Eva Nogales

PMC · DOI: 10.1038/s41594-024-01324-4 · 2025-04-25

## TL;DR

This paper discusses how cryo-electron microscopy is helping scientists study complex molecular structures in cells.

## Contribution

The paper highlights cryo-electron microscopy's role in studying increasingly complex and dynamic molecular assemblies.

## Key findings

- Structural biology is moving toward studying larger and more dynamic molecular assemblies.
- Cryo-electron microscopy is becoming a key tool for these complex studies.

## Abstract

Macromolecules are involved in myriads of interactions that regulate their cellular function. While years of structural biology progress was built by reducing this complexity, a molecular understanding of biological processes requires the characterization of ever larger and more dynamic molecular assemblies. Cryo-electron microscopy is rising to this challenge.

## Full-text entities

- **Chemicals:** glycerol (MESH:D005990), GRAFIX (-)

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Source: https://tomesphere.com/paper/PMC12027301