Vaginal candidiasis attributed to hair, skin, and nails supplement: a case report

TL;DR

A 64-year-old woman developed a vaginal yeast infection after taking a hair, skin, and nails supplement, suggesting a possible new link.

Contribution

This is the first documented case linking a hair, skin, and nails supplement to vaginal candidiasis.

Findings

A 64-year-old woman developed vaginal candidiasis after starting a hair, skin, and nails supplement.

The Naranjo scale indicated a probable association between the supplement and the infection.

No similar cases were found in the literature, suggesting a novel adverse effect.

Abstract

This case report presents the first documented instance of vaginal candidiasis linked to the intake of a hair, skin, and nails supplement.

A 64-year-old Caucasian female patient, with a history of chronic kidney disease and multiple comorbidities, developed symptoms of vaginal yeast infection after beginning the supplement. The adverse event was evaluated using the Naranjo Adverse Drug Reaction Probability Scale, scoring a 5, indicating a probable association. Despite extensive literature searches, no similar cases were found, suggesting this might be a unique reaction. This report highlights potential safety concerns with dietary supplements, particularly those not regulated by the Food and Drug Administration, underscoring the need for further investigation into their adverse effects.

The case emphasizes the importance of considering dietary supplements as potential contributors to adverse health events, especially in patients with complex medical histories.

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Introduction

Dietary supplements are utilized to help provide essential nutrients that the body needs to function properly [1]. Among the various types of supplements, hair, skin, and nails supplements, which are marketed by various brands, often referred to as “beauty supplements” are growing rapidly in popularity [2]. The National Health and Nutrition Examination survey has reported a nearly twofold use in these products [3]. Direct-to-consumer advertising and social media may play a larger role in this increase than ever before [4]. These products typically contain a blend of vitamins, minerals, and nutrients aimed at enhancing the health and appearance of hair, skin, and nails. Hair, skin, and nails supplements are not regulated as drugs by the Food and Drug Administration (FDA) and as such they are not tested for safety and efficacy. They are instead recognized as foods by the Dietary Supplement Health and Education Act [5, 6]. While certain adverse events have been reported and include acute reactions such as sedation and kidney stones as well as chronic toxicities such as gastrointestinal upset and increased incidence of dyslipidemia and hyperglycemia, no reports of vaginal candidiasis have been published [4]. The following case report describes a patient taking a hair, skin, and nails supplement who developed vaginal candidiasis. Vaginal candidiasis is a fungal infection characterized by symptoms such as itching and irritation in the vagina and vulva, a burning sensation, redness and swelling of the vulva, vaginal pain, and a thick, white, odor-free vaginal discharge [7]. There are multiple ingredients in a hair, skin, and nails supplement including vitamins A, B vitamins, C, D, E; folate; zinc; rutin; pantothenic acid; para-aminobenzoic acid; horsetail extract; inositol; and collagen [8]. Each of these ingredients was included in the medical literature database searches described below to investigate the causative agents and degree of prevalence in the population. This adverse event was then assessed using the Naranjo Adverse Drug Reaction Probability Scale to determine the likelihood of causality.

Case presentation

A 64-year-old Caucasian woman was seen in the nephrology clinic for the management of her chronic kidney disease on 7 June 2024. The patient’s past medical history was significant for stage 2 chronic kidney disease, hypertension, hyperlipidemia, arthritis, anemia of chronic kidney disease, fibromyalgia, peripheral vascular disease, gastroesophageal reflux disease, and urinary tract infections. Her estimated glomerular filtration rate (GFR) was > 60 ml/minute, blood pressure was 123/83 mmHg, and heart rate was 51 beats per minute. Her medications included albuterol 90 mcg hydrofluoroalkane (HFA) inhaler as needed, aspirin 81 mg daily, cholecalciferol 2000 IU daily, diclofenac 1% topical gel four times a day, docusate senna 2 capsule at bedtime, ezetimibe 10 mg daily, famotidine 40 mg at bedtime, ferrous sulfate 325 mg (65 mg elemental iron) daily, lisinopril 10 mg daily, metoprolol tartrate 100 mg twice daily, simvastatin 20 mg daily, and trazodone 200 mg at bedtime. The patient reported taking cranberry extract as well. Past medical history was positive for tobacco and negative for alcohol consumption. The patient started taking vitamin B12 and extra strength hair, skin, and nails supplement manufactured by Spring Valley in February after seeing the benefits of stronger nails and better skin from her cousin. The exact ingredients of Spring Valley Hair Skin and Nails supplement is listed in Table 1. After 3–4 weeks of taking the supplements daily, the patient started to experience dark, yellow, foul-smelling discharge from her vagina, and burning upon urination. The patient discontinued the supplement in mid-April and upon discontinuation, her symptoms improved.Table 1. Hair, skin, and nails supplement ingredients per daily dose (three caplets)Vitamin A1500 mcgVitamin C60 mgVitamin D25 mcgVitamin E6.75 mgThiamine5 mgRiboflavin2 mgNiacin25 mgVitamin B65 mgFolate333 mcgVitamin B128 mcgBiotin3000 mcgPantothenic acid15 mgCholine10 mgCalcium200 mgPhosphorus87 mgMagnesium50 mgZinc7.5 mgManganese2 mgPara aminobenzoic acid10 mgInositol30 mgRutin complex38 mgHorsetail3 mgCollagen50 mg

Methods

The Naranjo Adverse Drug Reaction Probability Scale was used to assess the probability that the hair, skin, and nails supplement was associated with the patient’s vaginal candidiasis. The Naranjo Adverse Drug Reaction Probability Scale (Tables 2) ranges from −4 to +13. If a score is 9 or higher, it is considered “definite,” if the score is 5–8 it is “probable,” if the score is 1–4 it is “possible,” and if the score is 0 or less it is “doubtful” [9]. The patient consented to the use of her medical information for this work and was interviewed. Responses from the interview and from the patient’s medical history were recorded on the Naranjo Adverse Drug Reaction Probability Scale instrument. A literature search was conducted using the key terms “hair, skin, and nail supplement”, “yeast infection”, “urinary tract infection”, “vitamin B12 supplement”, “vaginal candidiasis”, and “beauty supplements”. Additionally, each ingredient was searched with vaginal candidiasis. These searches were completed using PubMed, Google Scholar, and Embase. The limits were set to include any papers published in human subjects in the English language. No limits were set to select for publication types or study designs.Table 2. Naranjo adverse drug reaction probability scale [5]Score interpretation≥ 9 Definite: reaction (1) followed a reasonable temporal sequence after a drug or in which a toxic drug level had been established in body fluids or tissues, (2) followed a recognized response to the suspected drug, and (3) was confirmed by improvement on withdrawing the drug and reappeared on reexposure5–8 Probable: reaction (1) followed a reasonable temporal sequence after a drug, (2) followed a recognized response to the suspected drug, (3) was confirmed by withdrawal but not exposure to the drug, and (4) could not be reasonably explained by the known characteristics of the patient’s clinical state1–4 Possible: reaction (1) followed a temporal sequence after a drug, (2) possibly followed a recognized pattern to the suspected drug, and (3) could be explained by the characteristics of the patient’s disease≤ 0 Doubtful: reaction was likely related to factors other than a drug

Results

The Naranjo Adverse Drug Reaction Probability Scale reported a score of 5 for this adverse drug event, indicating probable cause (Table 3). The literature evaluation using the broad search methods described above returned no citations. No previous case reports on hair, skin, and nails supplements or their component ingredients as listed in the methods section observed vaginal candidiasis reactions.Table 3. Patient score using Naranjo adverse drug reaction probability scaleQuestionScore1. Are there previous conclusive reports on this reaction?No (+0)2. Did the adverse event appear after the suspected drug was administered?Yes (+2)3. Did the adverse reaction improve when the drug was discontinued or a specific antagonist was administered?Yes (+1)4. Did the adverse event reappear when the drug was re-administered?Do not know (+0)5. Are there alternative causes (other than the drug) that could on their own have caused the reaction?No (+2)6. Did the reaction reappear when a placebo was given?Do not know (+0)7. Was the drug detected in blood (or other fluids) in concentrations known to be toxic?No (+0)8. Was the reaction more severe when the dose was increased or less severe when the dose was decreased?Do not know (+0)9. Did the patient have a similar reaction to the same or similar drugs in any previous exposure?No (+0)10. Was the adverse event confirmed by any objective evidence?No (+0)Total score5: probable

Discussion

The objective of this case report was to highlight the possible association between use of a common hair, skin, and nails supplement and the presence of vaginal candidiasis. To the authors’ knowledge, this is the first reported case of a hair, skin, and nails supplement associated with vaginal candidiasis. The importance of this case is that it highlights the possibility of links between common, readily available products that patients use every day without the realization of unintended side effects. In this case, the patient would not normally consider that hair, skin, and nails treatment could be affecting her genitourinary system. No formal studies or randomized controlled trials have evaluated the likelihood of developing vaginal candidiasis from the routine use of these products. Furthermore, manufacturers do not have to prove that hair, skin, and nails supplements are safe or effective as they are not regulated by the FDA [6]. This severely limits the knowledge of adverse effects and relegates the reporting of such instances to case reports and anecdotal accounts. All other medication related causes for vaginal candidiasis in this case were investigated. This patient was on several prescribed medications, none of which were reported to cause vaginal candidiasis. Other known causes such as uncontrolled diabetes and antibiotic use were also ruled out. Although age, hormonal changes, stress, and immunity issues can be contributing factors to vaginal candidiasis, the physician did not believe these were contributory in this case. The patient’s reaction appeared after she started taking the hair, skin, and nails supplement and discontinued when she stopped. How vaginal candidiasis could be attributed to a hair, skin, and nails supplement is difficult to ascertain. Although the active ingredients have not been reported to cause vaginal candidiasis, there could be other inactive ingredients or preservatives that may alter the vaginal pH with extended use. Limitations to this work include the fact that this is only one patient, and more reports or randomized studies would be needed for definitive conclusions. The patient also did not receive a comprehensive review of her dietary habits and thus no information is available regarding foods that might affect vaginal pH. It could be that many consumers are unaware that vaginal candidiasis could be linked to something as seemingly benign as a hair, skin, and nails supplement and hence many cases may go unreported.

Conclusion

The patient case presented here reports an association between hair, skin, and nails and vitamin b12 supplementation and vaginal candidiasis. Hair, skin, and nails supplements, while increasing in popularity, are not regulated by the FDA as drugs and no controlled studies exist to evaluate their safe and effective use. This case report highlights one concern that may link this product to the development of vaginal candidiasis and is worth further investigation.