Indolent leukemic non-nodal mantle cell lymphoma with TP53 mutation misdiagnosed as chronic lymphocytic leukemia: a case report and literature review
彤璐 邱, 亚平 张, 琰 王, 雨洁 吴, 文瑜 施, 奕 夏
TL;DR
A rare case of non-nodal mantle cell lymphoma misdiagnosed as chronic lymphocytic leukemia highlights the importance of accurate diagnosis and cautious treatment.
Contribution
Highlights the clinical management of nnMCL with TP53 mutation through a case report and literature review.
Findings
nnMCL can present as an indolent disease despite TP53 mutations.
Misdiagnosis as CLL can lead to inappropriate treatment decisions.
Observation may be preferable to immediate treatment in selected nnMCL cases.
Abstract
白血病性非淋巴结型套细胞淋巴瘤（nnMCL）患者临床上通常表现为惰性病程，当无症状及治疗指征时，可采取观察随访。本文对1例被误诊为慢性淋巴细胞白血病（CLL）且携带TP53基因突变的nnMCL患者进行了回顾性总结，并结合文献复习。此病例强调了nnMCL与CLL鉴别诊断的重要性，且对于nnMCL患者，即使其存在TP53基因突变等高危生物学标志，采取严格的观察等待策略可能比立即进行治疗更适宜。
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Taxonomy
TopicsLymphoma Diagnosis and Treatment · Genetic factors in colorectal cancer · CNS Lymphoma Diagnosis and Treatment