# Indolent leukemic non-nodal mantle cell lymphoma with TP53 mutation misdiagnosed as chronic lymphocytic leukemia: a case report and literature review

## TL;DR

A rare case of non-nodal mantle cell lymphoma misdiagnosed as chronic lymphocytic leukemia highlights the importance of accurate diagnosis and cautious treatment.

## Contribution

Highlights the clinical management of nnMCL with TP53 mutation through a case report and literature review.

## Key findings

- nnMCL can present as an indolent disease despite TP53 mutations.
- Misdiagnosis as CLL can lead to inappropriate treatment decisions.
- Observation may be preferable to immediate treatment in selected nnMCL cases.

## Abstract

白血病性非淋巴结型套细胞淋巴瘤（nnMCL）患者临床上通常表现为惰性病程，当无症状及治疗指征时，可采取观察随访。本文对1例被误诊为慢性淋巴细胞白血病（CLL）且携带TP53基因突变的nnMCL患者进行了回顾性总结，并结合文献复习。此病例强调了nnMCL与CLL鉴别诊断的重要性，且对于nnMCL患者，即使其存在TP53基因突变等高危生物学标志，采取严格的观察等待策略可能比立即进行治疗更适宜。