Spindle Cell Rhabdomyosarcoma of the Hand in a Full-Term Newborn: A Case Report

TL;DR

A rare case of spindle cell rhabdomyosarcoma in a newborn's hand is reported, highlighting its unusual presentation and poor prognosis.

Contribution

This case report presents a rare instance of spindle cell RMS in a full-term newborn's hand with lymph node involvement.

Findings

The tumor was diagnosed as stage IRS 3 spindle cell RMS based on histopathology.

The patient underwent surgery and chemotherapy but died from treatment complications.

The case exhibits unusual features including age, gender, site, and poor outcome.

Abstract

Rhabdomyosarcoma (RMS) is a rare soft tissue tumor with the most common sites of origin in the genitourinary tract, head, and neck regions, and extremities are less commonly involved. Spindle cell RMS is a rare variant of RMS in infants. RMS is uncommon in the hand. We present a case of spindle cell RMS in the hand of a full-term female newborn with regional lymph node involvement. Based on histopathology, the diagnosis of spindle cell RMS was made in stage IRS 3 of the Intergroup Rhabdomyosarcoma Study Group (IRSG) staging system. The infant underwent complete surgical resection and axillary lymph node removal, followed by chemotherapy. She died from complications of chemotherapy a year after initiation of treatment. The age, gender, poor outcome, and site are unusual features for this type of RMS.

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