A Rare TPM3-NTRK1 fusion in a fetal pelvic mass
Maryam Kazelka, Lei Shao, Marty McGraw, Jennifer Neville Kucera
TL;DR
This paper reports a rare case of a fetal tumor with a specific genetic fusion, TPM3-NTRK1, and its diagnosis using imaging and pathology.
Contribution
The paper presents a rare case of congenital NTRK-rearranged sarcoma with TPM3-NTRK1 fusion in a fetus.
Findings
Sonographic, MRI, and pathological findings confirmed a rare fetal tumor with TPM3-NTRK1 fusion.
The tumor was identified as a malignant spindle cell sarcoma in a male fetus.
Early diagnosis is critical for managing such rare fetal tumors.
Abstract
Early recognition and characterization of soft tissue tumors is important for proper fetal and maternal care. Here, we present sonographic, fetal and postnatal MRI, and pathological findings of a rare case of congenital NTRK-rearranged malignant spindle cell sarcoma with TPM3-NTRK1 fusion in a male fetus.
Genes, proteins, chemicals, diseases, species, mutations and cell lines named across the full text — each resolved to its canonical identifier and authoritative record.
Click any figure to enlarge with its caption.
Figure 1
Figure 2
Figure 3
Figure 4
Figure 5
Figure 6Peer Reviews
No public reviews on file for this paper yet. If you reviewed it on a platform where reviews are public (OpenReview, ICLR, NeurIPS, ICML), you can paste yours below so the community can read it here.
Videos
No videos yet. Explain this paper in a talk, walkthrough, or lecture? Add one.
Taxonomy
TopicsNeuroblastoma Research and Treatments · Childhood Cancer Survivors' Quality of Life · Soft tissue tumor case studies