# A Rare TPM3-NTRK1 fusion in a fetal pelvic mass

**Authors:** Maryam Kazelka, Lei Shao, Marty McGraw, Jennifer Neville Kucera

PMC · DOI: 10.1016/j.radcr.2025.02.079 · 2025-03-15

## TL;DR

This paper reports a rare case of a fetal tumor with a specific genetic fusion, TPM3-NTRK1, and its diagnosis using imaging and pathology.

## Contribution

The paper presents a rare case of congenital NTRK-rearranged sarcoma with TPM3-NTRK1 fusion in a fetus.

## Key findings

- Sonographic, MRI, and pathological findings confirmed a rare fetal tumor with TPM3-NTRK1 fusion.
- The tumor was identified as a malignant spindle cell sarcoma in a male fetus.
- Early diagnosis is critical for managing such rare fetal tumors.

## Abstract

Early recognition and characterization of soft tissue tumors is important for proper fetal and maternal care. Here, we present sonographic, fetal and postnatal MRI, and pathological findings of a rare case of congenital NTRK-rearranged malignant spindle cell sarcoma with TPM3-NTRK1 fusion in a male fetus.

## Linked entities

- **Genes:** TPM3 (tropomyosin 3) [NCBI Gene 7170], NTRK1 (neurotrophic receptor tyrosine kinase 1) [NCBI Gene 4914]
- **Species:** Homo sapiens (taxon 9606)

## Full-text entities

- **Genes:** TPM3 (tropomyosin 3) [NCBI Gene 7170] {aka CAPM1, CFTD, CMYO4A, CMYO4B, CMYP4A, CMYP4B}, NTRK1 (neurotrophic receptor tyrosine kinase 1) [NCBI Gene 4914] {aka MTC, TRK, TRK1, TRKA, Trk-A, p140-TrkA}
- **Diseases:** soft tissue tumors (MESH:D012983), fetal pelvic mass (MESH:D005315), malignant spindle cell sarcoma (MESH:D012509)

## Figures

6 figures with captions in the complete paper: https://tomesphere.com/paper/PMC11937640/full.md

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Source: https://tomesphere.com/paper/PMC11937640