Epigenetic biomarkers of borderline personality disorder with severe suicidal behaviors

TL;DR

This study explores epigenetic changes in people with borderline personality disorder and severe suicidal behaviors, focusing on genes related to brain function and stress.

Contribution

The study identifies novel epigenetic biomarkers linked to BPD and suicidal behaviors using advanced methylation analysis.

Findings

Epigenetic alterations in BDNF and stress-related genes were found in BPD patients with severe suicidal behaviors.

GrimAge analysis revealed distinct methylation patterns in BPD and suicide attempter groups compared to controls.

Abstract

Borderline personality disorder (BPD) is associated with excess suicide risk, natural-cause mortality, comorbid medical conditions, poor health habits and stress related epigenomic alterations. This presentation will report findings of BDNF and stress system associated epigenetic alterations in a group of severely impaired BPD and suicidal patients. Further, findings of GrimAge – a state-of-the-art epigenetic age (EA) estimator- in patients with BPD and attempted suicide patients will be presented. Genome-wide methylation patterns were measured using the Illumina Infinum Methylation Epic BeadChip in whole blood from well characterized 97 BPD patients, 88 suicide attempters and 32 healthy controls.

None Declared