# Epigenetic biomarkers of borderline personality disorder with severe suicidal behaviors

## TL;DR

This study explores epigenetic changes in people with borderline personality disorder and severe suicidal behaviors, focusing on genes related to brain function and stress.

## Contribution

The study identifies novel epigenetic biomarkers linked to BPD and suicidal behaviors using advanced methylation analysis.

## Key findings

- Epigenetic alterations in BDNF and stress-related genes were found in BPD patients with severe suicidal behaviors.
- GrimAge analysis revealed distinct methylation patterns in BPD and suicide attempter groups compared to controls.

## Abstract

Borderline personality disorder (BPD) is associated with excess suicide risk, natural-cause mortality, comorbid medical conditions, poor health habits and stress related epigenomic alterations. This presentation will report findings of BDNF and stress system associated epigenetic alterations in a group of severely impaired BPD and suicidal patients. Further, findings of GrimAge – a state-of-the-art epigenetic age (EA) estimator- in patients with BPD and attempted suicide patients will be presented. Genome-wide methylation patterns were measured using the Illumina Infinum Methylation Epic BeadChip in whole blood from well characterized 97 BPD patients, 88 suicide attempters and 32 healthy controls.

None Declared