Getah Virus: A New Contaminant in Veterinary Vaccines

TL;DR

This paper discusses Getah virus as a new contaminant in live PRRSV vaccines, highlighting its potential risks and genomic features.

Contribution

The paper introduces Getah virus as a newly identified contaminant in veterinary vaccines and analyzes its biological hazards.

Findings

Getah virus was found as a contaminant in live PRRSV vaccines in recent studies.

The paper discusses the source and genomic characteristics of contaminating GETV strains.

GETV poses potential biological hazards to livestock farming.

Abstract

Vaccines are essential for the prevention and control of infectious diseases in livestock farming. Among these, live veterinary vaccines play an important role. The production of live vaccines requires high-level biosafety, toxicity and potential contaminants should be closely monitored. Unfortunately, other viral contaminants in commercial live-attenuated vaccines against a multitude of viruses have been discovered, which are difficult to detect and can cause huge losses. Similar situations have occurred in commercial live-attenuated vaccines against porcine reproductive and respiratory syndrome virus (PRRSV), which arouses our considerable interest.

Mycoplasma, reticuloendotheliosis virus (REV), avian leukosis virus (ALV), chicken infectious anemia virus (CIAV), bovine polyomavirus (BPV), bovine viral diarrhea virus (BVDV), and porcine circovirus (PCV) are considered common contaminants in live veterinary vaccines against Newcastle disease virus (NDV), fowlpox virus (FPV), infectious bursal disease virus (IBDV), classical swine fever virus (CSFV), pseudorabies virus (PRV), and porcine reproductive and respiratory syndrome virus (PRRSV). In the past five years, Getah virus (GETV), an arbovirus affecting many farming mammals, was reported as a new contaminant in live PRRSV vaccines in two previous studies, which arouses our considerable interest. Therefore, in this paper, we aim to analyze and discuss the source, biological hazard, and genomic characteristics of these contaminating GETV strains further.

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