Tracking the neurophysiological effects of proteinopathy into the pre-clinical stage of Alzheimer’s disease
Alex I Wiesman, Santiago I Flores-Alonso
TL;DR
This paper discusses how early signs of Alzheimer’s disease can be detected through brain activity changes before symptoms appear.
Contribution
It introduces a new method to track pre-clinical Alzheimer’s using brain signal patterns and connectivity changes.
Findings
Amyloid-β deposition correlates with slower brain oscillations in cognitively healthy adults.
Functional connectivity in the brain decreases over time in individuals with amyloid-β accumulation.
These changes can be observed before cognitive decline becomes evident.
Abstract
This scientific commentary refers to ‘Amyloid-β deposition predicts oscillatory slowing of magnetoencephalography signals and a reduction of functional connectivity over time in cognitively unimpaired adults’, by Scheijbeler et al. (https://doi.org/10.1093/braincomms/fcaf018).
Genes, proteins, chemicals, diseases, species, mutations and cell lines named across the full text — each resolved to its canonical identifier and authoritative record.
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Taxonomy
TopicsAlzheimer's disease research and treatments · Dementia and Cognitive Impairment Research · Neurological Disorders and Treatments