# Tracking the neurophysiological effects of proteinopathy into the pre-clinical stage of Alzheimer’s disease

## TL;DR

This paper discusses how early signs of Alzheimer’s disease can be detected through brain activity changes before symptoms appear.

## Contribution

It introduces a new method to track pre-clinical Alzheimer’s using brain signal patterns and connectivity changes.

## Key findings

- Amyloid-β deposition correlates with slower brain oscillations in cognitively healthy adults.
- Functional connectivity in the brain decreases over time in individuals with amyloid-β accumulation.
- These changes can be observed before cognitive decline becomes evident.

## Abstract

This scientific commentary refers to ‘Amyloid-β deposition predicts oscillatory slowing of magnetoencephalography signals and a reduction of functional connectivity over time in cognitively unimpaired adults’, by Scheijbeler et al. (https://doi.org/10.1093/braincomms/fcaf018).