High-Dose Insulin Therapy for Refractory Shock in a Polypharmacy Overdose of Calcium Channel Blocker and Oral Hypoglycemic Agent: A Case Report and Literature Review
Vinayak S R, Bipenthung N Jami, Austin J Mangaly, Krishnakumar R S, Gladson Vineeth, Chandni Radhakrishnan
TL;DR
This case report describes the successful use of high-dose insulin therapy in treating a severe overdose involving a calcium channel blocker and an oral hypoglycemic agent.
Contribution
The novelty lies in demonstrating HDI therapy's effectiveness in a complex polypharmacy overdose case when conventional treatments failed.
Findings
High-dose insulin therapy improved the patient's condition after conventional treatments failed.
The case highlights HDI as a promising treatment for refractory shock in polypharmacy overdose scenarios.
Literature review supports HDI as a potential therapeutic option in similar overdose cases.
Abstract
We report a case of polypharmacy overdose involving a calcium (Ca) channel blocker and an oral hypoglycemic agent, where conventional therapies failed to obtain the desired clinical outcome. High-dose insulin (HDI) therapy, a promising treatment regime in this regard, was carried out for our patient, and her condition improved over the subsequent days.
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Taxonomy
TopicsPoisoning and overdose treatments · Pharmacology and Obesity Treatment · Cardiac electrophysiology and arrhythmias