# High-Dose Insulin Therapy for Refractory Shock in a Polypharmacy Overdose of Calcium Channel Blocker and Oral Hypoglycemic Agent: A Case Report and Literature Review

## TL;DR

This case report describes the successful use of high-dose insulin therapy in treating a severe overdose involving a calcium channel blocker and an oral hypoglycemic agent.

## Contribution

The novelty lies in demonstrating HDI therapy's effectiveness in a complex polypharmacy overdose case when conventional treatments failed.

## Key findings

- High-dose insulin therapy improved the patient's condition after conventional treatments failed.
- The case highlights HDI as a promising treatment for refractory shock in polypharmacy overdose scenarios.
- Literature review supports HDI as a potential therapeutic option in similar overdose cases.

## Abstract

We report a case of polypharmacy overdose involving a calcium (Ca) channel blocker and an oral hypoglycemic agent, where conventional therapies failed to obtain the desired clinical outcome. High-dose insulin (HDI) therapy, a promising treatment regime in this regard, was carried out for our patient, and her condition improved over the subsequent days.