Complete genome sequence of Staphylococcus epidermidis B273 and its epidermicin NI01 biosynthesis plasmid
Keir Nicholas-Haizelden, Charlotte E. Chong, Norah Alqahtani, Samah E. Alsaadi, Malcolm J. Horsburgh
TL;DR
This paper presents the full genome sequence of a Staphylococcus epidermidis strain and a plasmid involved in producing a potent antimicrobial peptide.
Contribution
The study provides the complete genome sequence of S. epidermidis B273 and identifies the plasmid responsible for epidermicin NI01 biosynthesis.
Findings
The genome of S. epidermidis B273 includes a plasmid with the epidermicin NI01 biosynthetic gene cluster.
Epidermicin NI01 is a broad-spectrum type II antimicrobial peptide.
Abstract
The human skin commensal Staphylococcus epidermidis produces diverse, therapeutically relevant bacteriocins. We report the complete whole-genome sequence of the nasal isolate S. epidermidis B273, which contains a plasmid with the biosynthetic gene cluster for epidermicin NI01, a broad-spectrum type II antimicrobial peptide.
Genes, proteins, chemicals, diseases, species, mutations and cell lines named across the full text — each resolved to its canonical identifier and authoritative record.
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Taxonomy
TopicsAntimicrobial Peptides and Activities · Biochemical and Structural Characterization · Microbial Natural Products and Biosynthesis