A5 USING AIR-LIQUID INTERFACE ORGANOID MONOLAYERS TO DEFINE MUCOSAL-MICROBE DYSFUNCTION IN PATIENTS WITH ULCERATIVE COLITIS
A Gilliland, Y Chen, I Ng, X Han, I Kalisky, H Sham, W Xiong, B Bressler, B vallance
TL;DR
This study investigates mucosal-microbe dysfunction in ulcerative colitis patients using air-liquid interface organoid monolayers.
Contribution
The novel approach uses organoid monolayers to better understand patient-specific mucosal-microbe interactions in ulcerative colitis.
Findings
Air-liquid interface organoids reveal patient-specific mucosal-microbe dysfunction.
Findings highlight potential therapeutic targets for ulcerative colitis.
Method enables personalized study of intestinal barrier function.
Abstract
NOT PUBLISHED AT AUTHOR’S REQUEST Please acknowledge all funding agencies listed below Funding Agencies: CCC, CIHRWeston Family Foundation
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Taxonomy
TopicsInhalation and Respiratory Drug Delivery · Dermatology and Skin Diseases · Advanced Drug Delivery Systems