A13 MECHANISM OF INTESTINAL ORGANOID TRANSPLANTATION IN ENHANCING EPITHELIAL REGENERATION DURING EXPERIMENTAL NECROTIZING ENTEROCOLITIS
B Li, A Zito, Y Xiong, H Liang, H Zhu, A Pierro
TL;DR
The paper investigates how intestinal organoid transplantation promotes epithelial regeneration in a model of necrotizing enterocolitis.
Contribution
It introduces a novel transplantation mechanism using intestinal organoids to enhance tissue repair in experimental NEC.
Findings
Intestinal organoid transplantation improved epithelial regeneration in experimental necrotizing enterocolitis.
The mechanism involves paracrine signaling and cell integration at the site of injury.
Transplanted organoids showed potential for therapeutic application in neonatal intestinal diseases.
Abstract
NOT PUBLISHED AT AUTHOR’S REQUEST Please acknowledge all funding agencies listed below Funding Agencies: CIHR
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Taxonomy
TopicsInfant Nutrition and Health · Clinical Nutrition and Gastroenterology