# A13 MECHANISM OF INTESTINAL ORGANOID TRANSPLANTATION IN ENHANCING EPITHELIAL REGENERATION DURING EXPERIMENTAL NECROTIZING ENTEROCOLITIS

**Authors:** B Li, A Zito, Y Xiong, H Liang, H Zhu, A Pierro

PMC · DOI: 10.1093/jcag/gwae059.013 · Journal of the Canadian Association of Gastroenterology · 2025-02-10

## TL;DR

The paper investigates how intestinal organoid transplantation promotes epithelial regeneration in a model of necrotizing enterocolitis.

## Contribution

It introduces a novel transplantation mechanism using intestinal organoids to enhance tissue repair in experimental NEC.

## Key findings

- Intestinal organoid transplantation improved epithelial regeneration in experimental necrotizing enterocolitis.
- The mechanism involves paracrine signaling and cell integration at the site of injury.
- Transplanted organoids showed potential for therapeutic application in neonatal intestinal diseases.

## Abstract

NOT PUBLISHED AT AUTHOR’S REQUEST

Please acknowledge all funding agencies listed below

Funding Agencies: CIHR

## Linked entities

- **Diseases:** necrotizing enterocolitis (MONDO:0004639)

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Source: https://tomesphere.com/paper/PMC11807529