Resveratrol natural product inspired compound as a potent neuroprotectant against acute oxidative stress
Alec Simonson, Akshay Naraine, Samantha Maki, Kristina Nugent, Salvatore Lepore, Ken Dawson-Scully
TL;DR
A new compound inspired by resveratrol shows strong neuroprotective effects against acute oxidative stress in fruit flies.
Contribution
A novel resveratrol-inspired compound with improved druglike properties and potent neuroprotection is introduced.
Findings
RVM-6 prolongs synaptic viability in neuromuscular junctions under acute oxidative stress.
The compound works at sub-nanomolar concentrations, indicating high potency.
It outperforms resveratrol and its natural derivatives in neuroprotection.
Abstract
Resveratrol as well as natural products biosynthetically derived from it, have been shown to have protective effects against oxidative stress. However, these compounds possess poor druglike properties. At sub-nanomolar concentrations, a novel compound (RVM-6) inspired by a resveratrol natural product prolongs synaptic viability in neuromuscular junctions in D. melanogaster exposed to acute oxidative stress.
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Taxonomy
TopicsHistorical and Modern Theater Studies · Literature, Culture, and Aesthetics · Literary and Cultural Studies