# Resveratrol natural product inspired compound as a potent neuroprotectant against acute oxidative stress

## TL;DR

A new compound inspired by resveratrol shows strong neuroprotective effects against acute oxidative stress in fruit flies.

## Contribution

A novel resveratrol-inspired compound with improved druglike properties and potent neuroprotection is introduced.

## Key findings

- RVM-6 prolongs synaptic viability in neuromuscular junctions under acute oxidative stress.
- The compound works at sub-nanomolar concentrations, indicating high potency.
- It outperforms resveratrol and its natural derivatives in neuroprotection.

## Abstract

Resveratrol as well as natural products biosynthetically derived from it, have been shown to have protective effects against oxidative stress. However, these compounds possess poor druglike properties. At sub-nanomolar concentrations, a novel compound (RVM-6) inspired by a resveratrol natural product prolongs synaptic viability in neuromuscular junctions in
D. melanogaster
exposed to acute oxidative stress.