Unilateral Vogt-Koyanagi-Harada Disease With Two Distinct Choroidal Neovascular Membranes: A Case Report

TL;DR

This case report describes a rare instance of unilateral Vogt-Koyanagi-Harada disease with two distinct choroidal neovascular membranes and uveitis reactivation.

Contribution

The novelty lies in documenting a rare unilateral VKH case with two distinct choroidal neovascular membranes and successful treatment outcomes.

Findings

The patient presented with two distinct choroidal neovascular membranes.

Treatment with systemic and intravitreal agents led to a good clinical response.

Reactivation of posterior uveitis occurred twice during treatment.

Abstract

Vogt-Koyanagi-Harada (VKH) disease is a multisystem inflammatory disease that usually presents with bilateral panuveitis. Unilateral manifestations of VKH, albeit rare, have been described. Choroidal neovascularization may occur as a complication during the disease. Reactivation of uveitis may also occur during treatment.

A patient with unilateral features of VKH disease presented with two distinct types of choroidal neovascular membranes and two episodes of reactivation of posterior uveitis. He underwent treatment with a combination of systemic steroids/immunosuppressive agents, intravitreal anti-vascular endothelial growth factor (anti-VEGF) agents, and dexamethasone implants with good clinical response.

Patients with VKH disease need to be diagnosed early, treated adequately with a combination of systemic and ocular medication, and followed up diligently for any complication that may arise, to optimize visual acuity.

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