Genomic-Based Early Detection Screening: A Literature Review of Prospective Trials and Emerging Strategies for Gastrointestinal Cancers

TL;DR

This paper reviews genomic-based screening tests for early detection of gastrointestinal cancers and their potential to improve current screening methods.

Contribution

The paper highlights the performance of genomic-based tests in prospective trials and outlines new strategies for gastroenterologists.

Findings

Genomic-based tests show promise in early detection of gastrointestinal cancers.

Prospective clinical trials demonstrate the effectiveness of these tests.

New strategies are emerging for diagnosing individuals with cancer signals.

Abstract

Numerous genomic-based early detection screening tests are being developed. These tests have the potential to revolutionize current single-organ screening paradigms, especially in gastrointestinal cancers. In this review, we underscore the performance of these genomic-based early detection tests based on prospective clinical trials. Moreover, we discuss a professional advancement for gastroenterologists in the diagnostic assessment of individuals who are cancer signal positive.