Thymoma with recurrent opportunistic infections—a case report

TL;DR

A middle-aged woman with thymoma and recurring infections was diagnosed with Good’s syndrome, a rare condition involving immune deficiency.

Contribution

This case report highlights the clinical presentation and management of Good’s syndrome in a patient with thymoma.

Findings

The patient showed significant improvement with intravenous immunoglobulin therapy.

Thymoma was identified as a precursor to immunodeficiency in this case.

Good’s syndrome was confirmed through clinical and laboratory evaluation.

Abstract

Good’s syndrome (GS) is a rare adult-onset thymoma associated with acquired combined B-cell and T-cell immunodeficiency. It has similarities with Common variable immunodeficiency (CVID) in terms of hypogammaglobulinemia and significant risk of invasive bacterial and opportunistic infections. We still have a long way to go in understanding the pathogenesis of Good’s syndrome. Here, we describe a case of a middle-aged female with thymoma and recurrent opportunistic infections. Clinico-laboratory evaluation led to a diagnosis of GS and she showed good response to intravenous immunoglobulin. Clinicians should be aware that thymoma can precede the onset of immunodeficiency.

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