This paper is marked retracted in the scholarly record (OpenAlex). Interpret its findings with caution.
Retraction: Chitinase 1 regulates pulmonary fibrosis by modulating TGF-β/SMAD7 pathway via TGFBRAP1 and FOXO3
Chang-Min Lee, Chuan-Hua He, Jin Wook Park, Jae Hyun Lee, Suchitra Kamle, Bing Ma, Bedia Akosman, Roberto Cortez, Emily Chen, Yang Zhou, Erica L Herzog, Changwan Ryu, Xueyan Peng, Ivan O Rosas, Sergio Poli, Carol Feghali Bostwick, Augustine M Choi, Jack A Elias, Chun Geun Lee
TL;DR
This paper explores how Chitinase 1 influences lung fibrosis through interactions with TGFBRAP1 and FOXO3, suggesting a new therapeutic target.
Contribution
The study identifies the CHIT1/SMAD7 axis as a novel biomarker and therapeutic target for pulmonary fibrosis.
Findings
CHIT1 modulates TGF-β signaling via TGFBRAP1 and FOXO3 in pulmonary fibrosis.
The CHIT1/SMAD7 interaction is highlighted as a potential therapeutic target.
Abstract
Chitinase 1 (CHIT1) plays a role in the pathogenesis of pulmonary fibrosis by modulating canonical and noncanonical TGF-β signaling via interaction with TGFBRAP1 and FOXO3. These findings highlight the CHIT1/SMAD7 axis as a potential biomarker and therapeutic target of pulmonary fibrosis.
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Taxonomy
TopicsMarriage and Family Dynamics · Studies on Chitinases and Chitosanases · Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis