# Retraction: Chitinase 1 regulates pulmonary fibrosis by modulating TGF-β/SMAD7 pathway via TGFBRAP1 and FOXO3

## TL;DR

This paper explores how Chitinase 1 influences lung fibrosis through interactions with TGFBRAP1 and FOXO3, suggesting a new therapeutic target.

## Contribution

The study identifies the CHIT1/SMAD7 axis as a novel biomarker and therapeutic target for pulmonary fibrosis.

## Key findings

- CHIT1 modulates TGF-β signaling via TGFBRAP1 and FOXO3 in pulmonary fibrosis.
- The CHIT1/SMAD7 interaction is highlighted as a potential therapeutic target.

## Abstract

Chitinase 1 (CHIT1) plays a role in the pathogenesis of pulmonary fibrosis by modulating canonical and noncanonical TGF-β signaling via interaction with TGFBRAP1 and FOXO3. These findings highlight the CHIT1/SMAD7 axis as a potential biomarker and therapeutic target of pulmonary fibrosis.