Serum osteoglycin is stable during various glycemic challenges in healthy men

TL;DR

This study found that osteoglycin levels in healthy men remain stable during different glucose conditions, suggesting they are not affected by short-term changes in blood sugar or insulin.

Contribution

The study shows that serum osteoglycin levels are not influenced by glycemic challenges in healthy individuals.

Findings

Serum osteoglycin levels did not change significantly during oral glucose tolerance tests.

There were no significant differences in osteoglycin levels between fasting and non-fasting conditions.

Glucose and insulin levels did not affect circulating osteoglycin concentrations.

Abstract

Osteoglycin is hypothesized to be metabolically active and may enhance insulin action. We hypothesized that osteoglycin levels increase during hyperglycemia as a physiological response to enhance the effects of insulin.

Eight healthy males were included in a cross-over study consisting of three study days following an 8 h fast. First, we performed an oral glucose tolerance test (OGTT); second, an isoglycemic intravenous glucose infusion (IIGI); and third, a control period consisting of a three hour fast. We analyzed blood samples for circulating osteoglycin levels during the study days. Repeated measures ANOVA was performed to compare levels of s-osteoglycin between OGTT, IIGI, and the fasting control.

There were no differences in baseline osteoglycin levels among study days (p > 0.05). We observed no significant changes neither in absolute s-osteoglycin levels by time (p = 0.14) nor over time by study day (p = 0.99). Likewise, we observed no significant changes in percentage s-osteoglycin levels neither by time (p = 0.11) nor over time by study day (p = 0.89).

We found that s-osteoglycin levels were stable for three hours during OGTT, IIGI, and fasting in healthy males. Based on the present study, circulating s-osteoglycin levels may be measured independently of fasting or non-fasting conditions. Furthermore, circulating physiological levels of glucose and insulin did not affect s-osteoglycin levels.

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