# Serum osteoglycin is stable during various glycemic challenges in healthy men

## TL;DR

This study found that osteoglycin levels in healthy men remain stable during different glucose conditions, suggesting they are not affected by short-term changes in blood sugar or insulin.

## Contribution

The study shows that serum osteoglycin levels are not influenced by glycemic challenges in healthy individuals.

## Key findings

- Serum osteoglycin levels did not change significantly during oral glucose tolerance tests.
- There were no significant differences in osteoglycin levels between fasting and non-fasting conditions.
- Glucose and insulin levels did not affect circulating osteoglycin concentrations.

## Abstract

Osteoglycin is hypothesized to be metabolically active and may enhance insulin action. We hypothesized that osteoglycin levels increase during hyperglycemia as a physiological response to enhance the effects of insulin.

Eight healthy males were included in a cross-over study consisting of three study days following an 8 h fast. First, we performed an oral glucose tolerance test (OGTT); second, an isoglycemic intravenous glucose infusion (IIGI); and third, a control period consisting of a three hour fast. We analyzed blood samples for circulating osteoglycin levels during the study days. Repeated measures ANOVA was performed to compare levels of s-osteoglycin between OGTT, IIGI, and the fasting control.

There were no differences in baseline osteoglycin levels among study days (p > 0.05). We observed no significant changes neither in absolute s-osteoglycin levels by time (p = 0.14) nor over time by study day (p = 0.99). Likewise, we observed no significant changes in percentage s-osteoglycin levels neither by time (p = 0.11) nor over time by study day (p = 0.89).

We found that s-osteoglycin levels were stable for three hours during OGTT, IIGI, and fasting in healthy males. Based on the present study, circulating s-osteoglycin levels may be measured independently of fasting or non-fasting conditions. Furthermore, circulating physiological levels of glucose and insulin did not affect s-osteoglycin levels.