Ovarian Sertoli-Leydig Cell Tumors in a Three-Year-Old Child

TL;DR

A rare ovarian tumor causing virilization in a three-year-old girl is reported, highlighting the importance of considering this condition in young girls with similar symptoms.

Contribution

This case report presents the youngest known case of ovarian Sertoli-Leydig cell tumor, expanding clinical awareness for early diagnosis.

Findings

Ovarian Sertoli-Leydig cell tumors can present in very young children with virilization and abdominal mass.

Early diagnosis and histological evaluation are crucial for determining prognosis and treatment.

This case expands the known age range for such tumors and emphasizes the need for prompt clinical evaluation.

Abstract

Ovarian Sertoli-Leydig cell tumors (SLCT) are extremely rare malignant tumors deriving from the sex cord stroma. An abdominal mass and a virilization syndrome dominate the clinical symptoms. This particular tumor poses diagnostic and therapeutic problems. Prognosis depends on staging (the International Federation of Gynecology and Obstetrics (FIGO)/tumor, node, metastasis (TNM)) and differentiation. The treatment is surgical, combined with adjuvant chemotherapy in certain cases.

We report the case of a three-year-old girl admitted to our department for signs of virilization with an abdominal mass. The literature does not contain any reports of a younger case. Ovarian SLCTs should be considered in every girl presenting with signs of virilization and a lower abdominal mass. The prognosis and management depend on the results of the histological analysis and extension evaluation in order to define therapeutic management.

Figures