Progress of allogeneic hematopoietic stem cell transplantation in KMT2A-rearranged acute leukemia
竞 刘, 晓军 黄
TL;DR
This paper reviews the progress of allogeneic stem cell transplants in treating a type of leukemia with KMT2A rearrangements, focusing on outcomes and factors affecting success.
Contribution
The paper provides a comprehensive review of clinical advancements and outcomes of allo-HSCT for KMT2A-rearranged acute leukemia.
Findings
Allo-HSCT is increasingly used in KMT2A-rearranged acute leukemia with variable success.
Outcomes depend on factors like disease status and donor type in both children and adults.
Strategies to improve allo-HSCT outcomes are being explored.
Abstract
KMT2A重排急性白血病是具有独特生物学特性的一类白血病，其预后中等或不良。近年来，异基因造血干细胞移植（allo-HSCT）在KMT2A重排急性白血病中的应用日趋广泛。本文通过综述allo-HSCT治疗KMT2A重排急性白血病临床研究进展，分析allo-HSCT在儿童及成人KMT2A重排急性髓系白血病和急性淋巴细胞白血病中的疗效，归纳影响allo-HSCT预后的因素，并探讨可能改善allo-HSCT预后的方法。
Genes, proteins, chemicals, diseases, species, mutations and cell lines named across the full text — each resolved to its canonical identifier and authoritative record.
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Taxonomy
TopicsAcute Myeloid Leukemia Research