# Progress of allogeneic hematopoietic stem cell transplantation in KMT2A-rearranged acute leukemia

## TL;DR

This paper reviews the progress of allogeneic stem cell transplants in treating a type of leukemia with KMT2A rearrangements, focusing on outcomes and factors affecting success.

## Contribution

The paper provides a comprehensive review of clinical advancements and outcomes of allo-HSCT for KMT2A-rearranged acute leukemia.

## Key findings

- Allo-HSCT is increasingly used in KMT2A-rearranged acute leukemia with variable success.
- Outcomes depend on factors like disease status and donor type in both children and adults.
- Strategies to improve allo-HSCT outcomes are being explored.

## Abstract

KMT2A重排急性白血病是具有独特生物学特性的一类白血病，其预后中等或不良。近年来，异基因造血干细胞移植（allo-HSCT）在KMT2A重排急性白血病中的应用日趋广泛。本文通过综述allo-HSCT治疗KMT2A重排急性白血病临床研究进展，分析allo-HSCT在儿童及成人KMT2A重排急性髓系白血病和急性淋巴细胞白血病中的疗效，归纳影响allo-HSCT预后的因素，并探讨可能改善allo-HSCT预后的方法。