Dysarthria as a Presenting Symptom With Rapidly Progressive Imaging Features in Sporadic Creutzfeldt-Jakob Disease: A Case Report

TL;DR

This case report describes a rare and rapidly progressing brain disease that initially showed speech difficulties and unusual MRI findings.

Contribution

The paper presents a unique case of sCJD with atypical early symptoms and rapid imaging changes.

Findings

The patient showed dysarthria as the first symptom of sCJD.

MRI scans revealed rapid progression of neurological damage.

The case highlights the variability in sCJD clinical presentation.

Abstract

Sporadic Creutzfeldt-Jakob disease (sCJD) is a rare and fatal neurodegenerative disorder belonging to a group of diseases known as prion disease. Characterized by the formation of abnormal prion proteins in the brain, these conditions lead to tissue damage and vacuolation, giving the brain a sponge-like appearance. sCJD represents the most prevalent form of CJD, accounting for roughly 85% of all CJD cases. We report a case with unusual clinical manifestations. The patient experienced progressive neurological symptoms and MRI progression.

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