Immuno-histochemical evaluation of CD34 for OLP and OSMF

TL;DR

This study examines CD34 expression in oral lichen planus and oral submucous fibrosis, finding higher levels compared to normal tissue.

Contribution

The study identifies CD34 as a potential diagnostic marker for OLP and OSMF through immuno-histochemical evaluation.

Findings

CD34 expression was significantly higher in OLP and OSMF compared to normal controls.

Erosive OLP showed the highest CD34 expression, followed by OSMF and reticular OLP.

Abstract

Immuno-histochemical evaluation of CD34 in oral lichen planus (OLP) and Oral Submucous Fibrosis (OSMF) is of interest to dentist.20
specimens of normal oral mucosa (buccal mucosa/gingiva tissue) from patients who had extractions performed as part of orthodontic
treatment comprised Group I, the control group. Group II comprised 30 individuals with a diagnosis of oral lichen planus. 30 OSMF cases
with diagnoses is Group III. These 80 specimens were all given consideration when choosing for CD34immuno-histochemical staining. The
CD34 was greater in all categories of OLP and OSMF when compared to normal controls. Maximum CD34 expression was observed in erosive OLP
(147.41±17.60) followed by OSMF (116.01 ±11.72) and reticular OLP (105.01±11.62). Data was statistically significant
(p<0.001).Immunohistochemistry of CD34 evaluation is a potential diagnostic marker for OLP and OSMF.