# Immuno-histochemical evaluation of CD34 for OLP and OSMF

## TL;DR

This study examines CD34 expression in oral lichen planus and oral submucous fibrosis, finding higher levels compared to normal tissue.

## Contribution

The study identifies CD34 as a potential diagnostic marker for OLP and OSMF through immuno-histochemical evaluation.

## Key findings

- CD34 expression was significantly higher in OLP and OSMF compared to normal controls.
- Erosive OLP showed the highest CD34 expression, followed by OSMF and reticular OLP.

## Abstract

Immuno-histochemical evaluation of CD34 in oral lichen planus (OLP) and Oral Submucous Fibrosis (OSMF) is of interest to dentist.20
specimens of normal oral mucosa (buccal mucosa/gingiva tissue) from patients who had extractions performed as part of orthodontic
treatment comprised Group I, the control group. Group II comprised 30 individuals with a diagnosis of oral lichen planus. 30 OSMF cases
with diagnoses is Group III. These 80 specimens were all given consideration when choosing for CD34immuno-histochemical staining. The
CD34 was greater in all categories of OLP and OSMF when compared to normal controls. Maximum CD34 expression was observed in erosive OLP
(147.41±17.60) followed by OSMF (116.01 ±11.72) and reticular OLP (105.01±11.62). Data was statistically significant
(p<0.001).Immunohistochemistry of CD34 evaluation is a potential diagnostic marker for OLP and OSMF.