Linking IL-6 and hsCRP among Indian patients with myocardial infarction

TL;DR

This study shows that IL-6 and hsCRP levels are strongly linked and can help predict heart attacks in Indian patients.

Contribution

The study demonstrates a significant correlation between IL-6 and hsCRP as predictive biomarkers for myocardial infarction in an Indian population.

Findings

There is a significant correlation between IL-6 and hsCRP levels in quartile groups.

Elevated IL-6 and hsCRP levels are associated with lipid profiles and myocardial infarction risk.

Kaplan-Meier analysis supports the association between IL-6, hsCRP, and heart attack outcomes.

Abstract

The association between serum interleukin-6 (IL-6) and highly sensitive C - reactive protein (hsCRP) as predictors of the risk
factors for Myocardial Infarction. The study included a total of 50 patients with Myocardial Infarction, aged between 25 to 74 years.
The levels of hsCRP were measured using the immunoturbidimetry method, while Interleukin 6 was estimated using the sandwich ELISA method.
Statistical analysis was conducted using SPSS version 21.0, with p values calculated using Quartile ratio, ANOVA unpaired t-test, and
Kaplan-Meier Curve Method. A p-value of less than 0.05 was considered statistically significant. All participants underwent a
questionnaire, physical examination, medical history assessment, and laboratory tests. The results of the study showed that there was a
significant correlation between IL-6 and hsCRP levels in the Quartile groups, as well as with lipid profiles. The Kaplan-Meier method
also demonstrated a significant association between IL-6 and hsCRP levels in participants. The comparison of biomarkers further supported
these findings. Thus, data shows that elevated levels of hsCRP and IL-6 could serve as valuable diagnostic markers for predicting Acute
Myocardial Infarction. Our study strongly suggests that IL-6 could be a powerful marker in evaluating the Myocardial Infarction.

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