Diffuse Interstitial Lung Disease Revealing Antisynthetase Syndrome

TL;DR

A case study describes a 53-year-old woman whose interstitial lung disease led to the diagnosis of antisynthetase syndrome, which improved with corticosteroids and cyclophosphamide.

Contribution

This case highlights ILD as a revealing sign of antisynthetase syndrome and the effectiveness of corticosteroids and cyclophosphamide in managing it.

Findings

Interstitial lung disease can be the initial manifestation of antisynthetase syndrome.

Treatment with corticosteroids and cyclophosphamide showed favorable outcomes in the patient.

Abstract

Interstitial lung disease (ILD) is a frequent manifestation of connective tissue diseases. They may be revelatory of the disease or occur during follow-up. Antisynthetase syndrome (ASS) is a complex and heterogeneous autoimmune disorder. Antisynthetase antibodies, in particular the anti-Jo-1 antibody, characterize this syndrome. The occurrence and severity of ILD determine the prognosis, which in turn determines therapeutic management. We report the case of a 53-year-old female patient presenting with ILD, revealing the diagnosis of ASS. The evolution was favorable with bolus corticosteroids associated with cyclophosphamide.

Figures