# Diffuse Interstitial Lung Disease Revealing Antisynthetase Syndrome

## TL;DR

A case study describes a 53-year-old woman whose interstitial lung disease led to the diagnosis of antisynthetase syndrome, which improved with corticosteroids and cyclophosphamide.

## Contribution

This case highlights ILD as a revealing sign of antisynthetase syndrome and the effectiveness of corticosteroids and cyclophosphamide in managing it.

## Key findings

- Interstitial lung disease can be the initial manifestation of antisynthetase syndrome.
- Treatment with corticosteroids and cyclophosphamide showed favorable outcomes in the patient.

## Abstract

Interstitial lung disease (ILD) is a frequent manifestation of connective tissue diseases. They may be revelatory of the disease or occur during follow-up. Antisynthetase syndrome (ASS) is a complex and heterogeneous autoimmune disorder. Antisynthetase antibodies, in particular the anti-Jo-1 antibody, characterize this syndrome. The occurrence and severity of ILD determine the prognosis, which in turn determines therapeutic management. We report the case of a 53-year-old female patient presenting with ILD, revealing the diagnosis of ASS. The evolution was favorable with bolus corticosteroids associated with cyclophosphamide.