PH-binding motifs as a platform for drug design: Lessons from protease-activated receptors; PARs

Jeetendra Kumar Nag; Amnon Hoffman; Chaim Gilon; Beatrice Uziely; Rachel Bar-Shavit

PMC · DOI:10.18632/oncoscience.599·April 25, 2024

PH-binding motifs as a platform for drug design: Lessons from protease-activated receptors; PARs

Jeetendra Kumar Nag, Amnon Hoffman, Chaim Gilon, Beatrice Uziely, Rachel Bar-Shavit

PDF

Open Access

Abstract

Linked entities

Genes, proteins, chemicals, diseases, species, mutations and cell lines named across the full text — each resolved to its canonical identifier and authoritative record.

Genes16

PWAR1 AKT1 F2RL3 FZD4 RNF43 BMX ZNRF3 CTNNB1 VAV3 SRC SOS1 EGFR F2RL1 GAB1 JTB PIN4

Proteins16

Species2

Homo sapiens(human · species)Mus musculus(house mouse · species)

Chemicals4

cyclic peptide FZDs AYPGKF Herceptin

Diseases8

tumorigenesis colon, pancreas, stomach, ovary, endometrium, and liver cancers epithelial malignancies colon, breast and ovarian cancers toxicity Breast cancer cancer triple negative breast cancer

Mutations3

D349AH349AF347L

Figures1

Click any figure to enlarge with its caption.

Peer Reviews

No public reviews on file for this paper yet. If you reviewed it on a platform where reviews are public (OpenReview, ICLR, NeurIPS, ICML), you can paste yours below so the community can read it here.

Videos

No videos yet. Explain this paper in a talk, walkthrough, or lecture? Add one.

Taxonomy

TopicsBlood Coagulation and Thrombosis Mechanisms · Cancer-related gene regulation · Nuclear Receptors and Signaling