# PH-binding motifs as a platform for drug design: Lessons from protease-activated receptors; PARs

**Authors:** Jeetendra Kumar Nag, Amnon Hoffman, Chaim Gilon, Beatrice Uziely, Rachel Bar-Shavit

PMC · DOI: 10.18632/oncoscience.599 · 2024-04-25

## Full-text entities

- **Genes:** PWAR1 (Prader Willi/Angelman region RNA 1) [NCBI Gene 145624] {aka D15S227E, PAR-1, PAR1}, AKT1 (AKT serine/threonine kinase 1) [NCBI Gene 207] {aka AKT, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA}, F2RL3 (F2R like thrombin or trypsin receptor 3) [NCBI Gene 9002] {aka PAR4}, FZD4 (frizzled class receptor 4) [NCBI Gene 8322] {aka CD344, EVR1, FEVR, FZD4S, Fz-4, Fz4}, RNF43 (ring finger protein 43) [NCBI Gene 54894] {aka RNF124, SSPCS, URCC}, BMX (BMX non-receptor tyrosine kinase) [NCBI Gene 660] {aka ETK, PSCTK2, PSCTK3}, ZNRF3 (zinc and ring finger 3) [NCBI Gene 84133] {aka BK747E2.3, RNF203}, CTNNB1 (catenin beta 1) [NCBI Gene 1499] {aka CTNNB, EVR7, MRD19, NEDSDV, armadillo}, VAV3 (vav guanine nucleotide exchange factor 3) [NCBI Gene 10451], SRC (SRC proto-oncogene, non-receptor tyrosine kinase) [NCBI Gene 6714] {aka ASV, SRC1, THC6, c-SRC, p60-Src}, SOS1 (SOS Ras/Rac guanine nucleotide exchange factor 1) [NCBI Gene 6654] {aka GF1, GGF1, GINGF, HGF, NS4, SOS-1}, EGFR (epidermal growth factor receptor) [NCBI Gene 1956] {aka ERBB, ERBB1, ERRP, HER1, NISBD2, NNCIS}, F2RL1 (F2R like trypsin receptor 1) [NCBI Gene 2150] {aka GPR11, PAR2}, GAB1 (GRB2 associated binding protein 1) [NCBI Gene 2549] {aka DFNB26}, JTB (jumping translocation breakpoint) [NCBI Gene 10899] {aka HJTB, HSPC222, PAR, hJT}, PIN4 (peptidylprolyl cis/trans isomerase, NIMA-interacting 4) [NCBI Gene 5303] {aka EPVH, PAR14, PAR17, hEPVH, hPar14, hPar17}
- **Diseases:** tumorigenesis (MESH:D063646), colon, pancreas, stomach, ovary, endometrium, and liver cancers (MESH:D010051), epithelial malignancies (MESH:D002277), colon, breast and ovarian cancers (MESH:D061325), toxicity (MESH:D064420), Breast cancer (MESH:D001943), cancer (MESH:D009369), triple negative breast cancer (MESH:D064726)
- **Chemicals:** cyclic peptide (MESH:D010456), FZDs (-), AYPGKF (MESH:C455901), Herceptin (MESH:D000068878)
- **Species:** Homo sapiens (human, species) [taxon 9606], Mus musculus (house mouse, species) [taxon 10090]
- **Mutations:** D349A, H349A, F347L

## Figures

1 figure with captions in the complete paper: https://tomesphere.com/paper/PMC11065100/full.md

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Source: https://tomesphere.com/paper/PMC11065100