Alkyl ammonium hydrogen sulfate immobilized on Fe3O4@SiO2 nanoparticles: a highly efficient catalyst for the multi-component preparation of novel tetrazolo[1,5-a]pyrimidine-6-carboxamide derivatives
Mehdi Khalaj, Seyed Mahmoud Musavi, Majid Ghashang
TL;DR
A new catalyst helps efficiently create tetrazolo[1,5-a]pyrimidine-6-carboxamide derivatives using a three-component reaction.
Contribution
A novel catalyst based on Fe3O4@SiO2 nanoparticles is introduced for synthesizing tetrazolo[1,5-a]pyrimidine derivatives.
Findings
The catalyst Fe3O4@SiO2-(PP)(HSO4)2 enables high yields of tetrazolo[1,5-a]pyrimidine-6-carboxamide derivatives.
The reaction works efficiently in DMF and under solvent-free conditions.
Abstract
In this, a three-component reaction for the preparation of novel tetrazolo[1,5-a]pyrimidine-6-carboxamide derivatives from N,N′-(sulfonylbis(1,4-phenylene))bis(3-oxobutanamide), aldehydes and 1H-tetrazol-5-amine is reported. The application of Fe3O4@SiO2-(PP)(HSO4)2 (A) as a catalyst afforded the desired products (a1–a18) in high yields in DMF as solvent as well as under solvent-free conditions.
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Taxonomy
TopicsFinance, Taxation, and Governance · Administrative Law and Governance · Animal Law and Welfare