# Alkyl ammonium hydrogen sulfate immobilized on Fe3O4@SiO2 nanoparticles: a highly efficient catalyst for the multi-component preparation of novel tetrazolo[1,5-a]pyrimidine-6-carboxamide derivatives

## TL;DR

A new catalyst helps efficiently create tetrazolo[1,5-a]pyrimidine-6-carboxamide derivatives using a three-component reaction.

## Contribution

A novel catalyst based on Fe3O4@SiO2 nanoparticles is introduced for synthesizing tetrazolo[1,5-a]pyrimidine derivatives.

## Key findings

- The catalyst Fe3O4@SiO2-(PP)(HSO4)2 enables high yields of tetrazolo[1,5-a]pyrimidine-6-carboxamide derivatives.
- The reaction works efficiently in DMF and under solvent-free conditions.

## Abstract

In this, a three-component reaction for the preparation of novel tetrazolo[1,5-a]pyrimidine-6-carboxamide derivatives from N,N′-(sulfonylbis(1,4-phenylene))bis(3-oxobutanamide), aldehydes and 1H-tetrazol-5-amine is reported. The application of Fe3O4@SiO2-(PP)(HSO4)2 (A) as a catalyst afforded the desired products (a1–a18) in high yields in DMF as solvent as well as under solvent-free conditions.