Repulsive guidance molecule A (RGMA) is widely expressed in the CNS of the sea lamprey Petromyzon marinus during early development
Laura González-Llera, Michael I. Shifman, Antón Barreiro-Iglesias
TL;DR
The study shows that RGMA is widely expressed in the central nervous system of developing sea lamprey embryos and prolarvae.
Contribution
The novel contribution is the first report of RGMA expression in early developmental stages of sea lamprey embryos and prolarvae.
Findings
RGMA transcript is broadly expressed in the central nervous system of sea lamprey embryos and prolarvae.
Expression of RGMA follows a rostro-caudal gradient during early development.
Abstract
RGM interactions with its receptor Neogenin play an important role in the regulation of axonal guidance or cell death in the developing central nervous system. The sea lamprey RGMA transcript has been recently identified. However, its expression has been only studied in the spinal cord of mature (premetamorphic) larval sea lampreys. Here, we report the expression of the sea lamprey RGMA transcript in developing embryos and prolarvae by means of in situ hybridization. Our data show that the RGMA transcript is broadly expressed in the central nervous system of embryos and prolarvae and with a rostro-caudal gradient of expression.
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Taxonomy
TopicsDevelopmental Biology and Gene Regulation · Axon Guidance and Neuronal Signaling · Neurogenesis and neuroplasticity mechanisms