# Repulsive guidance molecule A (RGMA) is widely expressed in the CNS of the sea lamprey Petromyzon marinus during early development

## TL;DR

The study shows that RGMA is widely expressed in the central nervous system of developing sea lamprey embryos and prolarvae.

## Contribution

The novel contribution is the first report of RGMA expression in early developmental stages of sea lamprey embryos and prolarvae.

## Key findings

- RGMA transcript is broadly expressed in the central nervous system of sea lamprey embryos and prolarvae.
- Expression of RGMA follows a rostro-caudal gradient during early development.

## Abstract

RGM interactions with its receptor Neogenin play an important role in the regulation of axonal guidance or cell death in the developing central nervous system. The sea lamprey
RGMA
transcript has been recently identified. However, its expression has been only studied in the spinal cord of mature (premetamorphic) larval sea lampreys. Here, we report the expression of the sea lamprey
RGMA
transcript in developing embryos and prolarvae by means of in situ hybridization. Our data show that the
RGMA
transcript is broadly expressed in the central nervous system of embryos and prolarvae and with a rostro-caudal gradient of expression.