Cefepime-Induced Generalized Fixed Drug Eruption With Morbilliform Rash
Grayson P Clark, Haley M Caldwell, Christopher A Coop, Brittanie I Neaves, Peter W Barnes
TL;DR
A patient developed a widespread skin reaction from cefepime, which improved after stopping the drug and using antihistamines and steroids.
Contribution
This case highlights cefepime as a rare cause of generalized fixed drug eruption.
Findings
Cefepime can cause generalized fixed drug eruption with morbilliform rash.
Symptoms resolved after discontinuing cefepime and using antihistamines and topical steroids.
Abstract
Fixed drug eruption (FDE) is a cutaneous reaction that characteristically recurs in the same locations upon re-exposure to the offending drug(s). The typical presentation of FDEs is single or multiple violaceous plaques with hyperpigmentation due to inflammation. The causative agents for FDEs include antibiotics, nonsteroidal anti-inflammatory drugs (NSAIDs), acetaminophen, barbiturates, and anticonvulsants. We present an interesting case of a generalized fixed drug eruption secondary to cefepime that resolved with the cessation of the offending drug and the institution of antihistamines and topical steroids.
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Taxonomy
TopicsDrug-Induced Adverse Reactions · Blood disorders and treatments · Pharmacovigilance and Adverse Drug Reactions