# Cefepime-Induced Generalized Fixed Drug Eruption With Morbilliform Rash

## TL;DR

A patient developed a widespread skin reaction from cefepime, which improved after stopping the drug and using antihistamines and steroids.

## Contribution

This case highlights cefepime as a rare cause of generalized fixed drug eruption.

## Key findings

- Cefepime can cause generalized fixed drug eruption with morbilliform rash.
- Symptoms resolved after discontinuing cefepime and using antihistamines and topical steroids.

## Abstract

Fixed drug eruption (FDE) is a cutaneous reaction that characteristically recurs in the same locations upon re-exposure to the offending drug(s). The typical presentation of FDEs is single or multiple violaceous plaques with hyperpigmentation due to inflammation. The causative agents for FDEs include antibiotics, nonsteroidal anti-inflammatory drugs (NSAIDs), acetaminophen, barbiturates, and anticonvulsants. We present an interesting case of a generalized fixed drug eruption secondary to cefepime that resolved with the cessation of the offending drug and the institution of antihistamines and topical steroids.