A25 DETECTION OF BACTERIAL ADP-HEPTOSE BY INTESTINAL STEM CELLS DRIVES EPITHELIAL REGENERATION FROM PANETH CELL DEDIFFERENTIATION
S Goyal, S Gray-Owen, S E Girardin
TL;DR
Intestinal stem cells detect bacterial ADP-heptose, triggering epithelial regeneration through Paneth cell dedifferentiation.
Contribution
Discovers a novel mechanism where bacterial ADP-heptose activates intestinal stem cells for tissue repair.
Findings
Bacterial ADP-heptose is sensed by intestinal stem cells.
Paneth cell dedifferentiation supports epithelial regeneration.
This mechanism offers new insights into gut repair processes.
Abstract
NOT PUBLISHED AT AUTHOR’S REQUEST Please acknowledge all funding agencies listed below Funding Agencies CCC, CIHR
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Taxonomy
TopicsCancer Research and Treatments · Digestive system and related health