# A25 DETECTION OF BACTERIAL ADP-HEPTOSE BY INTESTINAL STEM CELLS DRIVES EPITHELIAL REGENERATION FROM PANETH CELL DEDIFFERENTIATION

## TL;DR

Intestinal stem cells detect bacterial ADP-heptose, triggering epithelial regeneration through Paneth cell dedifferentiation.

## Contribution

Discovers a novel mechanism where bacterial ADP-heptose activates intestinal stem cells for tissue repair.

## Key findings

- Bacterial ADP-heptose is sensed by intestinal stem cells.
- Paneth cell dedifferentiation supports epithelial regeneration.
- This mechanism offers new insights into gut repair processes.

## Abstract

NOT PUBLISHED AT AUTHOR’S REQUEST

Please acknowledge all funding agencies listed below

Funding Agencies

CCC, CIHR

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Source: https://tomesphere.com/paper/PMC10872062