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Ngoc Luu, Apratim Bajpai, Rui Li, Seojin Park, Mahad Noor, Xiao Ma, Weiqiang Chen
TL;DR
This study explores how aging affects the ability of vascular smooth muscle cells to sense mechanical forces, focusing on the role of the Piezo1 channel.
Contribution
The paper identifies Piezo1 as a mediator of aging-related decline in mechanosensation in vascular smooth muscle cells.
Findings
Aging leads to reduced mechanosensation in vascular smooth muscle cells.
Piezo1 channel activity is crucial for maintaining mechanosensation in these cells.
Restoring Piezo1 function may counteract age-related vascular dysfunction.
Abstract
Cover legend: The cover image is based on the Research Article Aging‐associated decline in vascular smooth muscle cell mechanosensation is mediated by Piezo1 channel by Ngoc Luu et al., https://doi.org/10.1111/acel.14036
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Taxonomy
TopicsErythrocyte Function and Pathophysiology · Blood properties and coagulation · Ion channel regulation and function