# Featured Cover

## TL;DR

This study explores how aging affects the ability of vascular smooth muscle cells to sense mechanical forces, focusing on the role of the Piezo1 channel.

## Contribution

The paper identifies Piezo1 as a mediator of aging-related decline in mechanosensation in vascular smooth muscle cells.

## Key findings

- Aging leads to reduced mechanosensation in vascular smooth muscle cells.
- Piezo1 channel activity is crucial for maintaining mechanosensation in these cells.
- Restoring Piezo1 function may counteract age-related vascular dysfunction.

## Abstract

Cover legend: The cover image is based on the Research Article Aging‐associated decline in vascular smooth muscle cell mechanosensation is mediated by Piezo1 channel by Ngoc Luu et al., https://doi.org/10.1111/acel.14036