The Various Roles of PEDF in Cancer
Mitra Elmi, Joshua H. Dass, Crispin R. Dass
TL;DR
This review explores how PEDF, a versatile protein, can both prevent and promote cancer through various molecular pathways.
Contribution
The paper provides a comprehensive overview of PEDF's dual roles in cancer progression and suppression.
Findings
PEDF exhibits anti-inflammatory, anti-angiogenic, and anti-tumour properties.
PEDF can enhance tumour response but also show pro-cancerous effects under certain conditions.
Metastatic and metabolic biomarkers are key to understanding PEDF's functional activity.
Abstract
Pigment epithelium-derived factor (PEDF) is a versatile protein with potent effects against various cancers. It hinders cancer initiation and spread. This review highlights some of the molecular pathways involved in PEDF’s anticancer properties. Pigment epithelium-derived factor (PEDF) is a natural immunomodulator, anti-inflammatory, anti-angiogenic, anti-tumour growth and anti-metastasis factor, which can enhance tumour response to PEDF but can also conversely have pro-cancerous effects. Inflammation is a major cause of cancer, and it has been proven that PEDF has anti-inflammatory properties. PEDF’s functional activity can be investigated through measuring metastatic and metabolic biomarkers that will be discussed in this review.
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Taxonomy
TopicsEconomic and Social Development · Regional Development and Innovation